Zonulin-Family-Protein-stool Zonulin-Family-Protein-stool
Zonulin Family Protein; stool Zonulin Family Protein; stool Zonulin Family Protein; stool

Zonulin Family Protein; stool

Elevated fecal levels of a zonulin family protein (ZFP) have been associated with metabolic syndrome and obesity; conditions that have been linked to increased intestinal permeability ("leaky gut"). Elevated serum levels of the ZFP antigen have been correlated with results from the established lactulose mannitol test. Definitive research has yet to be published regarding a correlation between fecal ZFP levels and the results of the lactulose mannitol test. [ LEARN MORE]

Useful for:

  • Celiac disease
  • Non-celiac gluten sensitivity
  • Type I diabetes
  • Juvenile nonalcoholic fatty liver disease
  • Multiple sclerosis
  • Rhuematoid arthritis
  • Asthma
  • Inflammatory bowel disease
  • Adult glucose intolerance

Turnaround Time

4 to 6 days

Note: Turnaround times on results are an estimate and are not guaranteed. The lab may need additional time due to holidays, confirmation/repeat testing, etc. You can contact us to discuss when your results should be ready.

Analytes Tested

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Analyte
CPT
ABN Required
Zonulin Family Protein; stool
83520
Yes

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Detailed Information

Elevated fecal levels of ZFP have been associated with metabolic syndrome, obesity, and apparently healthy cigarette smokers. High serum levels of ZFP (antigen) are correlated with abnormal results of the Lactulose Mannitol test; the long-accepted standard for intestinal permeability, but to date no such correlation has been reported with fecal ZFP. Excessive intake of simple sugars, sodium, emulsifiers, microbial transglutaminase (food additive) and nano-particles may also be triggers for increased fecal ZFP and intestinal permeability. Possible interventions to restore the gastrointestinal mucosal barrier include dietary changes, treatment of dysbiosis, digestive supports and anti-inflammatory supplements; specifically quercetin, vitamin C, curcumin, gamma-linoleic acid, omega-3 fatty acids (EPA, DHA), and aloe vera. Other nutrients such as zinc, beta-carotene, pantothenic acid, and L-glutamine may provide some support for rejuvenation of the mucosal barrier. The use of some probiotics has been shown to reduce serum and fecal zonulin levels, and inulin (about 10 grams per day) lowered serum zonulin after just five days in healthy young subjects. Consider a Comprehensive Stool Analysis to further investigate potential causes of increased intestinal permeability.