Titanium has been long regarded as an inert biocompatible metal due to its corrosion resistance. However recent studies have shown that Ti from non-bearing implant components can be released with potential consequential effects both locally and systemically. Ti may have adverse effects in blood, fibrotic tissues and osteogenic cells after transport through the circulatory or lymphatic systems. In a well-designed long-term animal model corrosion-released Ti increased blood Ti levels, and Ti concentrated primarily in the spleen and lungs to a lesser extent in the heart, kidneys and liver. [ LEARN MORE]
3 to 5 days
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